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Glucagon receptor activity is hypothesised to increase energy expenditure and promote fat breakdown (lipolysis), which researchers believe may contribute to the substantial weight loss observed in early trials though these mechanisms continue to be investigated

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In pancreatic beta cells, GLP-1 receptor activation enhances glucose-dependent insulin secretion

received honoraria for speaking at meetings from Novartis, Sanofi-Aventis, Lilly, AstraZeneca, Boehringer Ingelheim, and NovoNordisk

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Men using both therapies should establish baseline cardiovascular metrics before starting and schedule periodic monitoring, especially during the first three months of combined treatment