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Most patients notice appetite changes before seeing significant movement on the scale

Patients with insulin resistance or early-stage diabetes often report the re-emergence of pre-diabetic symptoms, such as: These symptoms may signal that the body is reverting to pre-treatment glucose dynamics and should not be ignored

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According to NICE guidance (TA875), Wegovy should be used alongside a reduced-calorie diet and increased physical activity as part of a comprehensive weight management programme

Weight loss of 3-5% is typical by this point for most patients

Data blending and conversions Data conversions and the combination of means and standard deviations were conducted using the Review Manager 5.4 (Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) calculator, in accordance with the guidelines outlined in the Cochrane Handbook for Systematic Reviews of Interventions [19]