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2014, 13:142 GLP-1R Signaling Binding of GLP-1 to GLP-1R triggers a downstream signaling cascade that induces a potent stimulation of glucose induced insulin secretion (GIIS) in pancreatic beta-cells, as well as inhibition of alpha cell glucagon release (6)

Although the detailed molecular mechanisms by which serotonin contributes to or ameliorates metabolic diseases are still rather obscure, this review provides a new perspective to understand, discover, and elucidate the function of serotonergic system in a spectrum of physiological and pathological conditions

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Results GLP-1R-expressing neurons are juxtaposed to DA terminals in the LS The GLP-1R is highly expressed within the LS, 10 a brain region in which DAT-expressing DA terminals reside

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