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NewsHealth Weight loss drug GLP-1 may have potential to treat depression, improve motivation, study suggests The blockbuster GLP-1 drugs taken by many Americans for diabetes and to aid in weight loss may also have potential for treating major depression, a new study finds

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Preclinical data indicated that tirzepatide exhibited an affinity for GIPR equivalent to GIP binding, while its affinity for GLP-1R was approximately five times weaker compared to GLP-1 (63)