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Iwai T, Ito S, Tanimitsu K, Udagawa S, Oka J

Second, their pharmacokinetics, efficacy, and relationship between the pharmacokinetics and adverse events are summarized

In addition, a meta-analysis of 1193 patients with baseline SGLT2i use in AMPLITUDE-O and Harmony Outcomes revealed an HR for MACE of 0.78 (95% CI 0.491.24) with SGLT2is and 0.77 (95% CI 0.680.87) without SGLT2is ( P -value for interaction 0.95), and an HR for HHF of 0.34 (95% CI 0.120.96) with SGLT2is and 0.72 (95% CI 0.550.92) without SGLT2is ( P -value for interaction 0.18) [48]

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They attenuate disease severity and histological inflammation in both DSS and T cell-mediated colitis models

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