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Thyroid hormone over-replacement is associated with increased risks of atrial fibrillation or flutter (AF/Aflutter) and stroke, especially in older individuals with T2D and obesitypopulations already at elevated cardiovascular risk [30,31,32,33,34,35]

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Wait 30 minutes before the first food, beverage, or other oral medications of the day Waiting less than 30 minutes or taking with food, beverages (other than plain water), or other oral medications will lessen the effect of RYBELSUS by decreasing absorption

At the end of the study (median follow-up 6.2 years) the incidence of both co-primary outcomes did not differ significantly between treatment groups

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