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In an AD mouse model, 6-month-old APP/PS1 mice showed significantly elevated cerebral Igfbp2 transcripts compared to wild-type controls [8]

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Conversely, repeated freeze-thaw cycles can damage peptide structure through physical stress to the molecular conformation

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Metabolic conditions : Hyperparathyroidism, gout, inflammatory bowel disease, type 2 diabetes/metabolic syndrome (particularly for uric acid stones due to low urine pH), and certain genetic disorders affecting urinary chemistry increase susceptibility

120 did not report significant findings related to inflammatory markers