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The change from baseline in ALT with semaglutide was significantly greater vs placebo (18.1% vs 1.1%)

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/ HbA1c 2,02% T2D

The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression

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However, from an industrial perspective, the more important shift is how retatrutide reshape global peptide API demand across upstream supply chains