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GLP-1 RA glucagon-like peptide 1 receptor agonists, CI confidence interval, MACE major adverse cardiovascular event, MI myocardial infarction, SBP systolic blood pressure in mmHg, HR hazard ratio, RR relative risk, HF heart failure, LVEF left-ventricular ejection fraction a Primary or secondary outcome of interest as reported by the study Statistically significant confidence interval Major Adverse Cardiac Events Among Patients with T2DM Strong evidence supports using GLP-1 RAs to reduce MACE among patients with T2DM and established CVD

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But the glucagon-related adjustment does not, so skipping the titration entirely is not recommended

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What if my sweet cravings don't go away

Dietary adjustments are often the first line of self-management: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods, which can worsen nausea Eat slowly and chew food thoroughly Stay well hydrated, particularly if experiencing diarrhoea or vomiting