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This disturbance of the intestinal flora disrupts the integrity of the gut barrier, increasing gut permeability to LPS, and the resultant activation of the TLR-4/NF-B-mediated inflammatory response

Davalintide ( AC2307 ), a novel amylin-mimetic peptide : enhanced pharmacological properties over native amylin to reduce food intake and body weight

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N Engl J Med 2016;375:183444.ArticlePubMed 36