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Additionally, a recent animal study demonstrated that combining the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 with GLP-1 effectively suppresses food intake and reduces body weight [29]

Indeed, GIPR agonism can blunt the nauseating effects of GLP-1R agonists in humans (52)

36 Future efforts to identify predictive biomarkers, which are more likely to benefit from GLP-1 RAs, will be key to stratifying patients based on likely therapeutic response or risk of side effects

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Proactive consultation with a GP or diabetes specialist is essential to develop a personalised management plan balancing maternal metabolic health with infant safety

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