are glp-1 agonists safe Is for Weight Loss? Peptides, Benefits & Risks MYTH BUSTER #1 “Weight-loss injections

cAMP signalling in insulin and glucagon secretion

GLP-1Rs are also present in juxtaglomerular cells that secrete renin

Weight regain is very common after stopping a GLP-1on average, up to two-thirds of the lost weight is regained within one year

Pharmacological effects of GIP, GLP-1 and their mimetics The pharmacological benefits of GIP, GLP-1, and their synthetic mimetics arise from their pleiotropic effects, encompassing at least five key functions: bolstering insulin secretion and survival of pancreatic -cells and modulating glucagon release by the pancreatic -cells in response to glycemic levels, acting on the satiety center in brain, slowing gastric emptying, regulating lipid and glucose metabolism through effects on adipose tissue and liver, and reducing systemic blood pressure

1992, Song et al

Its important to note that just four days ago, a paper in the American Journal of Ophthalmology found that there was no significant increase in risk of NAION or (ischemic optic neuropathy) in patients taking semaglutide or GLP-1 drugs compared to control group patients with Type 2 diabetes or high BMI