glp 1 inhibitors mechanism of action Mechanisms of GLP-1RA GLP-1 receptor agonists (GLP-1RAs): cardiovascular
Description
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On one hand, GLP1RAs (such as Exendin4) can effectively inhibit the expression and activity of L-type voltage-gated calcium channels (L-VGCCs) under hyperglycaemic conditions, thereby reducing calcium overload caused by excessive calcium influx, preventing the activation of downstream neuronal apoptosis pathways
& Roy, D
The binding of GLP-1RA to GLP-1R activates adenyl cyclase, which facilitates the conversion of ATP to cAMP
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