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Description
GLP-1R-mediated dopaminergic modulation may vary by drug class: in alcohol models, suppression of dopamine release is coupled with reduced locomotor sensitization [7,24], whereas in psychostimulant paradigms, GLP-1R activation primarily blunts drug-induced dopamine overflow without abolishing baseline dopaminergic tone [10]
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In PIONEER-2, oral semaglutide reduced CRP, whereas empagliflozin did not, despite similar weight loss
