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Some explanations for these strong effects come from mechanistic studies investigating the proportions of the respective GLP-1 and GIP receptor agonistic properties
Nelladulto obeso trattato con semaglutide o tirzepatide la massa magra e il volume muscolare possono diminuire in termini assoluti, ma la riduzione in larga parte proporzionata al calo ponderale e non equivale a un danno del muscolo
This finding is also consistent with that reported with liraglutide [36]
They should also be instructed about signs and symptoms that warrant dose adjustment or medical evaluation, including severe gastrointestinal side effects or other unusual symptoms that may indicate adverse reactions, as determined relevant by the prescribing clinician
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Karasawa T, Choi RH, Meza CA, et al
