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However, when both sygl-1 and lst-1 were removed, GLD-1(q361) protein increased dramatically in the distal germline ( Fig 6E ), with quantitation revealing a three-fold increase on average ( Fig 6F )
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Therefore, conducting studies under thermoneutral conditions may provide a way to evaluate treatment effects in CNS GIPR KO mice independently of body weight defence mechanisms and temperature-associated thermogenesis

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