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Humira (adalimumab) Disease area(s): Immunology Manufacturer(s): AbbVie 2024 Sales (USD): $8.99 billion Why it sold so well: In 2024, Humira remained a significant revenue contributor for AbbVie, despite facing substantial declines due to biosimilar competition following its US loss of exclusivity in January 2023

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b Dose listed correspond to those tested in cardiovascular outcome trials and may differ from approved weight loss regimens

The c-Jun N-terminal kinase mediates the induction of oxidative stress and insulin resistance by palmitate and toll-like receptor 2 and 4 ligands in 3T3-L1 adipocytes