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Retatrutide produced concentration-dependent increases in contractile force starting at 10 nanomolar concentrations and reaching plateau at 100 nanomolar

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The brain, after the pancreas, contains the highest density of GLP-1 receptors helping explain GLP-1s impact on appetite regulation and satiety (see Figure 1)

Pancreatic Effects of Liraglutide or Sitagliptin in Overweight Patients With Type 2 Diabetes: A 12-Week Randomized, Placebo-Controlled Trial