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doi: 10.7150/thno.30787
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Safety, Tolerability, and Who Should Consider This Dose A 40-unit maintenance dose is generally well-tolerated in individuals without contraindications, though gastrointestinal side effects (nausea, constipation, diarrhea) remain common, particularly during escalation
Prescriptions not guaranteed
GLP-1R agonism causes a small rise (usually 23 bpm) in heart rate (149), GIP infusion increases heart rate in humans (60) and GCGR agonism appears to have a positive chronotropic and inotropic action on the heart (150)
The Ace-K in Coke Zero also leaves a slightly different aftertaste than the aspartame-only Diet Coke some people notice it, some dont (Healthline)
