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In this context, as a result of increased vascular permeability, the surfactant secreted by type 2 pneumocytes becomes dysfunctional and as a result, the alveoli collapse and the instability in the lung tissue leads to pulmonary dysfunction [6870]

2.6 Rapid Weight Loss and Lean Mass Weight loss induced by GLP-1 therapy includes both: Fat mass Lean mass Clinical trials suggest approximately 2040% of weight lost may consist of lean tissue if adequate protein intake and resistance training are not maintained. Reduced lean mass and inadequate protein intake may indirectly influence: Iron status Zinc intake B vitamin intake This secondary pathway reduced dietary density during rapid weight loss is a central nutritional consideration and will be explored in detail in the next section

( 10.1038/s41467-020-14309-w) [DOI] [PMC free article] [PubMed] [Google Scholar] Baggio LL & Drucker DJ

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