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26 , 27 Rossetti y colaboradores publicaron desde 1987 los resultados con florizina, glucsido extrado de la corteza del manzano, que redujo la glucemia en ratas pancreatectomizadas y bloqueaba SGLT1 y SGLT2

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Due to the wide distribution of GLP-1R, GLP-1RAs also have a wide range of pharmacological effects

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In addition, hyperinsulinemia is responsible for the increase in the androgen production through both the direct stimulation of insulin receptors and the cross-reaction with Insulin-like Growth Factor-1 (IGF-1) receptors expressed on thecal cells [14]

doses 0.5-10 mg) studies in healthy subjects (HS), followed by a 4-week multiple-dose Phase 1 b proof-of-concept (POC