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Description
This demonstrates that hormones secreted from the gastrointestinal tract during oral glucose administration are involved in promoting pancreatic insulin secretion
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Clinical trials initially focused on its ability to improve glycemic control in adults whose diabetes was not adequately managed by first-line drugs such as metformin

It's worth noting that GLP-1 receptor agonists rarely cause hypoglycaemia unless combined with insulin or sulfonylureas, so this is an unlikely cause of headaches for most patients
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This effect was a result of a combination of a reduction in food intake and a shift in metabolic fuel preference to favor fat utilization
