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Description
Strategies that may reduce side effects include: Eating smaller meals Avoiding high-fat or heavy foods Maintaining hydration Following the prescribed titration schedule Serious but Rare Risks Serious side effects are uncommon but may include: Pancreatitis Gallbladder disease Severe dehydration Kidney complications (often related to dehydration) There is also a boxed warning regarding thyroid C-cell tumors observed in animal studies
[1] [2] Proper storage directly impacts medication potency
Conflicts of Interest The authors declare no conflict of interest

However, native GLP-1 has a very short half-life only about 12 minutes because it is rapidly degraded by the enzyme DPP-4 (dipeptidyl peptidase-4)

Although the result was contrary to a previous study, which might partly result from different animal species, assessment method for osteoclast number and drug dose, the bone resorption efficiency of osteoclasts declined in this experiment, leading to decreased bone resorption overall (30)

The survey finding is no surprise: GLP-1s work by mimicking a hormone produced in the gut to suppress a person's appetite and regulate blood sugar
