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Studies show that 20-40% of users experience some level of nausea or other GI symptoms, especially in the first weeks of treatment

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Therefore, hormonal influence on taste cells may regulate taste signaling, but taste receptors seem to regulate local hormone release which indicates a fine-tuning mechanism for dietary feedback

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Furthermore, FXR activation seems to reduce the degree of fatty liver disease [118] by increasing fatty acid oxidation [119] and inhibiting PPAR- expression [120]