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DMH LepR neurons receive afferents from the lateral hypothalamus (LH) Vglut2 neurons, which are known to be necessary for the rapid responses to food cues [54]

[162] In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [163] ) funded by the company, that people using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug

Smaller meals are easier to digest and may lessen nausea

Should You Microdose GLP-1s

Semaglutide slows digestion but current research shows no dangerous interactions with common blood thinners

Hypoglycemia risk: Patients taking GLP-1 agonists with insulin or sulfonylureas need close glucose monitoring, as dose adjustments of these medications may be necessary