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Exclusion criteria: Non-RCTs (cohort, casecontrol, cross-sectional studies, case reports)

who reported a significantly greater glutamine/glutamate ratio in streptozotocin-induced diabetic mice treated with 0.4 mg/kg liraglutide.Reference Gateva, Hristov and Ivanova 26 In addition, when mice had pentylenetetrazole-induced epilepsy, there were significant reductions in GABA and increased glutamate, which were prevented through pre-treatment with liraglutide post-mortem.Reference Koshal and Kumar 30 Separately, Rebosio et al