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The compounded formulation is prepared by licensed U.S.-based pharmacies that follow federal and state compounding guidelines

The next generation of GLP-1s, which is expected to be launched next year, may demonstrate amplified effects that could include improved neuroprotection, Thiara says, but its impact would need to be validated through rigorous clinical trials, she stated

Although other trials, for example the SUSTAIN 6 trial evaluating semaglutide for potential cardiovascular benefits in patients with type 2 diabetes, did not find a sex difference in the rate of reported GI events (51% more than placebo in men, 47% more than placebo in women) or in the rate of treatment discontinuation due to adverse events (76% more than placebo in men, 127% more than placebo in women)