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While there have been some concerns raised by health agencies about the potential negative psychological impact of GLP1-RAs, these reports have been inconsistent

At a very early age they are severely insulin resistant but not diabetic because of their hyperinsulinemic response, DeFronzo said

GLP-1 agonists have demonstrated anti-inflammatory effects in the central nervous system, potentially breaking this feedback loop

Non-Invasive Neurostimulation Methods for Acute and Preventive Migraine Treatment: A Narrative Review

J Health Psychol

Ocular hypertension triggers the production of pro-inflammatory cytokines by immune cells, which in turn drives the transformation of neuroprotective astrocytes into a neurotoxic A1-reactive phenotype, ultimately leading to RGC degeneration [45]