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Notably, two participants exited the study due to anxiety (placebo group) and food aversion (liraglutide 1.2 mg group)

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Moiz and colleagues found that retatrutide 12 mg weekly (Eli Lilly) showed the greatest effect on obesity among all agents in the review, producing weight loss of up to 22.1% (95% CI, 19.3%-24.9%) after 48 weeks of treatment

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Over-the-counter (OTC) weight-loss medications Theres only one over-the-counter medication for weight loss thats been approved by the FDA, and thats Alli, a brand name of the drug orlistat