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Independent testing and MHRA enforcement activity (including Operation Pangea) have found that many such products contain incorrect concentrations, impurities, or in some cases entirely different substances to those labelled

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In the Phase 2 trial, 72% of participants who had prediabetes at the start had normal glycated hemoglobin levels at 48 weeks, compared to just 22% on placebo

However, these risks were comparable in other instances with tirzepatide and controls (placebo, insulin, and GLP-1RA) in subgroup analyses according to tirzepatide dose (Table 2)

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