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14 A 2017 meta-analysis of 52 randomized, controlled trials that evaluated DPP-4 inhibitors' effects on beta-cell function found that, in monotherapy studies, all agents except linagliptin resulted in improvements in cell function

The retrospective matched cohort study involved 16,827 patients evaluated by neuro-ophthalmologists from 2017 to 2023

Echocardiographic studies demonstrate that GLP-1 agonists improve global longitudinal strain, an early marker of subclinical diabetic cardiomyopathy, by 1520% [79]

Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME, et al

Future research must focus on developing precision medicine strategies, expanding indications through rigorous trials, and creating accessible and affordable solutions to combat the ever-increasing global burden of CVD and related metabolic disorders

Impact on DR Semaglutide was first flagged as having potential ophthalmic complications in the SUSTAIN-6 study