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The lack of an increased CV risk in SUSTAIN 6 and PIONEER 6 is consistent with evidence from a meta-analysis summarizing data from SUSTAIN and PIONEER glycemic efficacy trials, which included patients with T2D at relatively low CV risk ( Cardiovascular Safety of Other GLP-1RAS To date, seven CVOTs have been conducted with GLP-1RAs ( Figure 2

Dulaglutide (Trulicity): The initial dose is 0.75 mg subcutaneously once weekly, which can be increased to 1.5 mg weekly after four weeks if required

A 2020 Step 1 Trial, published in the New England Journal of Medicine , showed significant weight loss results in participants with chronic weight management needs

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Higher doses, while more effective for weight loss, may increase the risk of exacerbating reflux symptoms, whereas lower doses may have a lesser impact