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This occurs because tirzepatide slows gastric emptying and alters gut motility, leading to increased fermentation of undigested carbohydrates by colonic bacteria

This is often due to peripheral vasoconstriction, where the body pulls blood away from the skin to protect the core

The rates of severe hypoglycemia, pancreatitis, and acute kidney injury did not differ substantially between groups

Tirzepatide shelf life and proper reconstitution technique affect medication efficacy

Effect estimates remained robust when restricting to patients with available hemoglobin A1c and including it in the propensity score (Supplementary Table 23)

Krasner NM, Ido Y, Ruderman NB, Cacicedo JM