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doi: 10.1016/S0140-6736(11)60205-5 52 AllisonDBGaddeKMGarveyWTPetersonCASchwiersMLNajarianTet al

Millions of people start GLP-1 therapy with high hopes, yet not everyone achieves the same dramatic weight loss results seen in clinical trials

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Semaglutide and liraglutide may reduce alcohol consumption in individuals with AUD owenhaskins Nov 14, 2024 2 min read A joint study by the University of Eastern Finland and Karolinska Institutet in Sweden has found that the GLP-1 agonists semaglutide and liraglutide, which are used for treating diabetes and obesity, were associated with fewer hospitalisations among individuals with alcohol use disorder (AUD)

Their mechanisms include: Neurotransmitter release : They increase the release of dopamine and noradrenaline in the brain Reuptake inhibition : They block the reuptake of these neurotransmitters, prolonging their activity Cognitive enhancement : In ADHD, they improve attention, focus, and impulse control Appetite suppression : As a secondary effect, they typically reduce appetite through central mechanisms Cardiovascular stimulation : They increase heart rate and blood pressure through sympathetic nervous system activation Lisdexamfetamine is a prodrug that is converted to dexamfetamine in the body and provides a longer duration of action (typically up to 14 hours), while dexamfetamine is available in immediate-release tablets (lasting 3-5 hours)