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Its bioactive compounds contribute to reducing glucose levels without observable toxicity

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GLP-1 medications can help manage type 2 diabetes and obesity, but they may cause short-term mild-to-moderate side effects such as nausea, vomiting, diarrhoea, constipation, bloating, and decreased appetite, particularly at the beginning of treatment

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125,126 As they demonstrated with a series of conformationally constrained GLP-1 analogs, the helical segments at the N- and C-terminal regions of the peptide appear to be important for receptor interaction

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Many patients do not realize that weight-loss medications require special perioperative consideration, so explicit disclosure is critical even if not directly asked

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Vagus nerve stimulation (VNS): A novel therapeutic frontier Several studies have conceptualized treating obesity with the use of electrical stimulation of the stomach and performed initial animal and human studies in 1990s (Cigaina et al

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[DOI] [PubMed] [Google Scholar] 216.Shintani T, Higashi S, Suzuki R, Takeuchi Y, Ikaga R, Yamazaki T, et al

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