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Common side effects reported in trials include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite Abdominal discomfort or bloating These effects are generally dose-dependent and tend to improve over time as the body adapts to the medication

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Kidney disease: Patients with diabetic kidney disease benefit from kidney protection, especially after the FLOW trial results

Another limitation refers to the exploratory nature of the analysis of the potential factors influencing the response to the intervention, which were not powered adequately in the conception of the investigation