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doi: 10.1038/s41573-021-00337-8

Specifically, GLP-1RAs reduce SREBP-2 expression via activation of the SIRT6-AMPK pathway, resulting in decreased expression of cholesterol and bile acid synthesis genes, and increased expression of genes associated with RCT and LDL-C uptake

Currently, there is no FDA-approved indication for GLP-1 receptor agonists in the treatment of Crohn's disease or any form of IBD

Communicate with your provider if side effects become a hurdle

In the absence of disease-specific response markers, biomarkers of neurodegeneration, which would be expected to change in response to disease-modifying therapies, may be of use in the evaluation of interventions for AD/ADRD

Safety data At least one treatment-emergent adverse event occurred in 86.4% of all participants, with a similar proportion of orforglipron participants experiencing an adverse event as placebo