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Description

Tirzepatide A once-weekly subcutaneous single-molecular dual agonist (GLP-1 and GIP), tirzepatide has a binding affinity for the GLP-1 receptor that is five times lower than that of native GLP-1 and a similar affinity for the GIP receptor has a binding affinity for the GLP-1 receptor that is five times lower than that of native GLP-1 and a similar affinity for the GIP receptor as native GIP [95], a finding subsequently corroborated by additional investigations

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Comparison of Ocular Complications and Other Outcomes Among Patients With Preexisting Diabetic Retinopathy With vs Without GLP-1 RA Prescriptions

GLP-1 is rapidly degraded by the dipeptidyl peptidase-4 enzyme (DPP-4) requiring the development of DPP-4 resistant peptide analogues to generate robust efficacy