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In a case study published yesterday in Nature Medicine, researchers found that tirzepatide (Mounjaro/Zepbound) can temporarily suppress signaling in the brains reward center

The integration of large-scale, multi-ethnic genetic data remains important for refining our understanding and enhancing the predictive precision of genetic influences on these conditions

Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

Certain microbes ferment fiber into short-chain fatty acids like butyrate, which directly stimulate GLP-1 release from intestinal L-cells and improve glucose control, appetite signaling, and metabolism

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Whenever possible, we carried out experiments in all groups of mice and age-matched littermate controls