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Except for linagliptin, which is eliminated via a biliary route, all other DPP-4 inhibitors are excreted in the urine ( DPP-4 inhibitors are contraindicated in type 1 diabetes as well as during pregnancy and lactation

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Gao R, Tao Y, Zhou C, et al

New England Journal of Medicine 3731122

Hwang E, Portillo B, Williams KW.New 11.Direct and Indirect Effects of Liraglutide on Hypothalamic POMC and NPY/AgRP Neurons - Implications for Energy Balance and Glucose Control.Molecular Metabolism