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2, right panel), with statistical significance reached in the obese class I and obese class IIIII subgroups

In recent years, autophagy, as a critical lysosome-dependent self-degradative process to maintain homeostasis, has been shown to be involved in the vascular endothelium damage in diabetes

Adipose tissue produces hormones such as leptin and estrogen (through aromatization of androgens), both of which influence bone density

These medications are being studied for their potential to support appetite control, blood sugar regulation, fat loss, and metabolic improvement

Beyond weight loss, GLP-1 RAs show promise for cardiovascular disease, dementia prevention, mast cells, and immune conditions

A moderate carbohydrate intake (100-150g/day from whole food sources) is likely more suitable, though no clinical study has directly tested this