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Clinical Kidney Journal

40 A dose-dependent pattern of body-weight reduction was observed, with the patients receiving the maximum dose of 0.4mg per day achieving a mean 13% weight loss, while the Placebo group exhibited a mean loss of 1%

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In addition, in vitro models of primary human adipose stem cells, researchers detected intracellular fat content and quantitative expression of early and mature adipocyte markers (PPAR, FABP4, and HSL), demonstrating that glucagon can significantly reduce adipocyte differentiation, inhibit adipocyte proliferation and adipogenesis

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