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Higher doses of semaglutide are associated with more side effects, including fatigue

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Shaking the vial can cause mechanical stress that shears the long, delicate amino acid chains of the peptide

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With decreasing urine volume, the bad molecules in urine can come together more easily and form stones. Lower urine volume creates conditions in which stoneforming molecules can crystallize more easily

semaglutide 1.0 mg (58 AEs) compared with semaglutide 0.5 mg (44 AEs) and placebo (42 AEs) (Table 3)