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Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

Because semaglutide is a peptide medicine that would normally be broken down in the stomach, the tablet has a special absorption-enhancing ingredient called salcaprozate sodium (SNAC)

Its the storage phase not the act of reconstitution that raises concerns about room temperature, since prolonged exposure outside refrigeration accelerates degradation and shortens the solutions usable window

However, if these effects persist or worsen, you should consult your healthcare provider

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