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Abstract Traditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities

In comparison to existing GLP-1RAs, our findings align with previous studies demonstrating their anti-obesity and glucose-regulation effects 17

Old habits reassert themselves

While many symptoms improve over time, GI discomfort remains a leading reason for discontinuation, reinforcing the need for gradual dose titration, patient education, and a personalized approach when choosing a GLP-1 therapy

Exendin-4 was totally new to science and yet curiously familiar

And then there's this: "A recent study came out showing about 22% developed nutritional deficiencies by one year on a GLP-1 medication," said Cohen