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glp 1 agonist and dpp 4 inhibitor Cardiovascular effects of the DPP-4 inhibitors dpp-4_inhibitors [TUSOM | Pharmwiki]
Description
NICE guidance (NG28) recommends considering GLP-1 receptor agonists for adults with type 2 diabetes when glycaemic targets are not achieved with other therapies, particularly in those with established cardiovascular disease or at high cardiovascular risk
![glp 1 agonist and dpp 4 inhibitor Cardiovascular effects of the DPP-4 inhibitors dpp-4_inhibitors [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/dpp4.png?w=600&tok=f9724b)
However, its bioavailability is lower , and gastrointestinal side effects may be more pronounced compared to injectables
![glp 1 agonist and dpp 4 inhibitor Cardiovascular effects of the DPP-4 inhibitors dpp-4_inhibitors [TUSOM | Pharmwiki]](https://s3.pgkb.org/pathway/PA166350061.png?versionId=i0uRR6th1JfjRbyBAMuvG79jLjYc4pDX)
That gap between mazdutide and retatrutide is not trivial
![glp 1 agonist and dpp 4 inhibitor Cardiovascular effects of the DPP-4 inhibitors dpp-4_inhibitors [TUSOM | Pharmwiki]](https://www.frontiersin.org/files/Articles/440649/fendo-10-00080-HTML/image_m/fendo-10-00080-g001.jpg)
Strategy is a hypothesis to be tested every quarter
![glp 1 agonist and dpp 4 inhibitor Cardiovascular effects of the DPP-4 inhibitors dpp-4_inhibitors [TUSOM | Pharmwiki]](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/090f/11898734/cf679742cf4f/cells-14-00387-g002.jpg)
Regulates Blood Lipid Levels: Helps lower cholesterol and triglyceride levels, contributing to better heart health
![glp 1 agonist and dpp 4 inhibitor Cardiovascular effects of the DPP-4 inhibitors dpp-4_inhibitors [TUSOM | Pharmwiki]](https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12933-022-01474-z/MediaObjects/12933_2022_1474_Fig4_HTML.png)
Can J Biochem