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The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism and appetite, and is an important target for treatment of type II diabetes and obesity

A study led by researchers from Columbia University Irving Medical Center, who assessed the cost-effectiveness of a range of anti-obesity medications in adolescents, have concluded that top-dose phentermine and topiramate (Qsymia) as adjunct to lifestyle counselling was estimated to be cost-effective after five years

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