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Wang B, Zhang J, Song F, Tian M, Shi B, Jiang H, et al

Degradation of circadian regulator The circadian clock is endogenous and controls numerous cellular physiological processes, including iron metabolism, oxidative stress, and cell death, by regulating circadian switches (25)

Aged animals may therefore benefit more from the effect of resveratrol

26 Sirtuins manipulate the metabolism reprogramming via directedly altering the activity of metabolic enzymes by NAD + -dependent modification or changing their expression by regulating transcription factors

When Nrf2 is activated, fumarate binds with cysteine residues in the Keap1 protein [73]