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[DOI] [PubMed] [Google Scholar] 39.Buse J.B., Nauck M., Forst T., Sheu W.H., Shenouda S.K., Heilmann C.R

preprocessing will include quality control, normalization with empirical-Bayes batch correction (e.g., ComBat), imputation of missingness using k-nearest neighbors (KNN), or multivariate chained equations as appropriate and feature scaling prior to fusion and modeling [93]

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This triple mechanism is designed to address appetite suppression, energy expenditure, and glucagon secretion in parallel, producing a more comprehensive effect on cellular metabolism than either predecessor