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Wootten et al., 2016

[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Samii A., Nutt J.G., Ransom B.R

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Jardiance is a member of a class of medications known as sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors), which control day-to-day blood sugar by reducing the reabsorption of filtered glucose in the kidneys, resulting in increased urinary excretion of glucose and lowered blood sugar concentrations

Consistent with a role of vagal afferents and vagal afferent GLP-1 receptors in the eating-inhibitory effect of peripheral endogenous GLP-1, virus-mediated knockdown of GLP-1R in vagal afferent neurons increased meal size, accelerated gastric emptying, and reduced prandial insulin secretion in rats, while not affecting 24 h food intake or body weight [518]